Antiproliferative agent-30
Product Specifications
CAS Number
2713553-88-7
Target
Microtubule Associated, FLT, Others, Bcr-Abl
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Cytoskeletal Signaling, Others
Bioactivity
Antiproliferative agent-30 (Compound 8g) exhibits broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM against HCT-116, K562, and MV-4-11 cancer cell lines, respectively. It inhibits tubulin assembly, FLT3, and Abl1 kinases and shows vascular-disrupting capabilities. Additionally, it displays an anticancer effect against acute myeloid leukemia (AML) with FLT3-ITD-TKD mutations [1].
Smiles
O(C)C=1C=C(C=2C=3C(NN2)=NC=C(C3)C4=CC(NCCO)=C(C)C=C4)C=C(OC)C1OC
Molecular Formula
C24H26N4O4
Molecular Weight
434.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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