OATD-02
Product Specifications
CAS Number
2146132-73-0
Target
Arginase
Related Pathways
Immunology/Inflammation
Bioactivity
OATD-02 is an orally active, competitive, reversible, noncovalent inhibitor with slow offset kinetics that targets both Arginase1 and Arginase2, exhibiting inhibitory concentrations (IC50) of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1) . Notably, OATD-02 mitigates tumor immunosuppression provoked by these arginases and has potential application in melanoma research [1].
Smiles
C(O)(=O)[C@]1(N)[C@H](CN(C)C)CC[C@@H](CCB(O)O)C1
Molecular Formula
C12H25BN2O4
Molecular Weight
272.15
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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