PD-L1-IN-3
Product Specifications
CAS Number
2953044-29-4
Target
PD-1/PD-L1
Related Pathways
Cell Cycle/Checkpoint, Immunology/Inflammation, Apoptosis
Purity
0.9947
Bioactivity
PD-L1-IN-3 (Compound 4a) functions as an inhibitor of the PD-1/PD-L1 axis, with an IC50 value of 4.97 nM for PD-L1 inhibition and an EC50 value of 2.70 μM for Jurkat T cell modulation. It antagonizes the PD-1/PD-L1 interaction by binding to the PD-L1 dimer, obstructing PD-1 signaling. This compound is utilized in research pertaining to lung cancer and melanoma [1].
Smiles
[Cl].N#CC1=C(OCC2=CC=C(C=C2)CN)SC=C1C=3C=CC(F)=CC3
Molecular Formula
C19H15ClFN2OS
Molecular Weight
373.85
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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