Semapimod
Product Specifications
CAS Number
352513-83-8
Target
Others, p38 MAPK, Interleukin, TNF
Related Pathways
Apoptosis, MAPK, Others, Immunology/Inflammation
Bioactivity
Semapimod is an inhibitor of proinflammatory cytokine production, capable of suppressing TNF-α, IL-1β, and IL-6. It hinders TLR4 signaling with an IC50 of approximately 0.3 μM, impedes p38 MAPK, and reduces nitric oxide production in macrophages. This compound shows promise for treating various inflammatory and autoimmune disorders [1] [2] [3].
Smiles
C(=NNC(=N)N)(C)C1=CC(C(=NNC(=N)N)C)=CC(NC(CCCCCCCCC(NC2=CC(C(=NNC(=N)N)C)=CC(C(=NNC(=N)N)C)=C2)=O)=O)=C1
Molecular Formula
C34H52N18O2
Molecular Weight
744.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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