SB-1295
Product Specifications
Target
Apoptosis, Reactive Oxygen Species, CDK
Related Pathways
Metabolism, Cell Cycle/Checkpoint, Apoptosis, Immunology/Inflammation, NF-κB
Bioactivity
SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 μM, exhibits antiproliferative effects on HCT 116 and MIA PaCa-2 cells. It promotes cell death in MIA PaCa-2 by elevating intracellular ROS levels, diminishing mitochondrial membrane potential, and triggering apoptosis. This compound holds potential for cancer research [1].
Molecular Formula
C23H22ClNO6
Molecular Weight
443.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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