Antibacterial agent 144
Product Specifications
Target
Others|||DNA/RNA Synthesis|||Antibacterial
Related Pathways
Cell Cycle/Checkpoint|||Microbiology/Virology|||Others|||DNA Damage/DNA Repair
Bioactivity
Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin. It acts by disrupting the bacterial cytoplasmic membrane and inhibiting biofilm formation. Additionally, it binds to human serum albumin (HSA) with a dissociation constant (Kd) of 13.2 ?M, enhancing its bactericidal activity. This compound also forms a supramolecular complex with DNA, thereby hindering DNA replication [1].
Molecular Formula
C26H23N7O3
Molecular Weight
481.51
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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