PRMT5-IN-31
Product Specifications
Target
Apoptosis, Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic, Apoptosis
Bioactivity
PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 and establishing key interactions with amino acid residues. It exhibits antiproliferative properties against A549 cells through induction of apoptosis and inhibition of cell migration, while demonstrating high metabolic stability in human liver microsomes (T1/2: 132.4 min) [1].
Molecular Formula
C21H24N2O2
Molecular Weight
336.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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