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FGFR-IN-11

Product Specifications

CAS Number

2658488-68-5

Target

FGFR

Related Pathways

Tyrosine Kinase/Adaptors, Angiogenesis

Bioactivity

FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, with IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4) . This compound demonstrates nanomolar potency in inhibiting the proliferation of various cancer cells and significantly hinders tumor growth in xenograft mouse models [1].

Smiles

O(C=1C2=C(C=C(OC)C(=C2)C3CCN(C(C=C)=O)CC3)N=CC1)C4=CC(Cl)=C(NC(NC5CC5)=O)C=C4

Molecular Formula

C28H29ClN4O4

Molecular Weight

521.01

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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