FGFR-IN-11
Product Specifications
CAS Number
2658488-68-5
Target
FGFR
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis
Bioactivity
FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, with IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4) . This compound demonstrates nanomolar potency in inhibiting the proliferation of various cancer cells and significantly hinders tumor growth in xenograft mouse models [1].
Smiles
O(C=1C2=C(C=C(OC)C(=C2)C3CCN(C(C=C)=O)CC3)N=CC1)C4=CC(Cl)=C(NC(NC5CC5)=O)C=C4
Molecular Formula
C28H29ClN4O4
Molecular Weight
521.01
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
bsm-52062R-PerCP-Cy5.5 100 µL
Cytokeratin 4 Recombinant Antibody, PerCP-Cy5.5 Conjugated
Ask
View Details 
VK515064-01 50 µg
Anti-Influenza A virus (H17N10) HA/Hemagglutinin Polyclonal Antibody
Ask
View Details 
VK515064-02 100 µg
Anti-Influenza A virus (H17N10) HA/Hemagglutinin Polyclonal Antibody
Ask
View Details