JET-209
Product Specifications
Target
Histone Acetyltransferase|||PROTACs
Related Pathways
Chromatin/Epigenetic|||PROTAC
Bioactivity
JET-209 is a potent proteolysis-targeting chimera (PROTAC) that effectively degrades CBP/p300, exhibiting half-maximal degradation concentration (DC50) values of 0.05 nM for CBP and 0.2 nM for p300. The compound comprises lenalidomide (the cereblon ligand), a connecting linker, and GNE-207 (the bromodomain inhibitor) . JET-209 is utilized in cancer research [1].
Molecular Formula
C46H47N9O6
Molecular Weight
821.92
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Curated Selection
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