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AMPK activator 11

Product Specifications

CAS Number

2948304-00-3

Target

AMPK|||OXPHOS|||Mitochondrial Metabolism

Related Pathways

Apoptosis|||Metabolism|||Chromatin/Epigenetic|||PI3K/Akt/mTOR signaling

Bioactivity

AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative phosphorylation (OXPHOS) (mitochondrial metabolism) . This compound demonstrates particular efficacy in inhibiting RKO xenograft growth, rendering it useful for anti-tumor and metabolic disease research [1].

Smiles

C(=O)C1=C(NC=2C1=CC=CC2)C=3N=C(NCCC4=CC=C(O)C=C4)C5=C(N3)C=CC=C5

Molecular Formula

C25H20N4O2

Molecular Weight

408.45

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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