AMPK activator 11
Product Specifications
CAS Number
2948304-00-3
Target
AMPK|||OXPHOS|||Mitochondrial Metabolism
Related Pathways
Apoptosis|||Metabolism|||Chromatin/Epigenetic|||PI3K/Akt/mTOR signaling
Bioactivity
AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative phosphorylation (OXPHOS) (mitochondrial metabolism) . This compound demonstrates particular efficacy in inhibiting RKO xenograft growth, rendering it useful for anti-tumor and metabolic disease research [1].
Smiles
C(=O)C1=C(NC=2C1=CC=CC2)C=3N=C(NCCC4=CC=C(O)C=C4)C5=C(N3)C=CC=C5
Molecular Formula
C25H20N4O2
Molecular Weight
408.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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