MC-EVCit-PAB-MMAE

MC-EVCit-PAB-MMAE (Linker-Payload 11), a conjugate used in antibody-drug conjugates (ADCs), consists of the MC-EVCit-PAB linker connected to the potent tubulin polymerization inhibitor MMAE [1].

[C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OCC3=CC=C(NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCCN4C(=O)C=CC4=O)=O)CCC(O)=O)=O)[C@H](C)C)=O)CCCNC(N)=O)=O)C=C3)=O)C)C(C)C)=O)[C@@H](C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]