PD-1/PD-L1-IN-34
Product Specifications
CAS Number
2924403-17-6
Target
PD-1/PD-L1
Related Pathways
Cell Cycle/Checkpoint, Apoptosis, Immunology/Inflammation
Bioactivity
PD-1/PD-L1-IN-34 (Compound (1S,2S) -A25) effectively inhibits the PD-1/PD-L1 interaction (IC50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1 (KD = 0.1554 μM), resulting in the activation of the immune microenvironment and suppression of tumor growth [1].
Smiles
ClC=1C([C@@H]2[C@H](C2)C3=C(C)C(=CC=C3)C4=CC=CC=C4)=CC(OCC5=CC(C#N)=CC=C5)=C(CNC(C(O)=O)(C)C)C1
Molecular Formula
C35H33ClN2O3
Molecular Weight
565.1
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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