URAT1&XO inhibitor 2
Product Specifications
CAS Number
1239488-96-0
Target
Xanthine Oxidase, OAT
Related Pathways
Membrane transporter/Ion channel, Metabolism
Bioactivity
Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM for XO inhibition. It effectively impedes uric acid uptake in HEK293 cells with URAT1 expression, evidenced by a Ki of 0.145 μM. In hyperuricemic mice models, the compound has been shown to reduce serum urate levels and uric acid excretion, indicating potential utility for hyperuricemia research [1].
Smiles
C(\CC1=CC=C(Br)C=C1)(=N\O)/C2=C(O)C=C(O)C=C2
Molecular Formula
C14H12BrNO3
Molecular Weight
322.15
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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