Bcl-2-IN-11
Product Specifications
CAS Number
2760536-88-5
Target
Bcl-2 Family, Others
Related Pathways
Others, Apoptosis
Bioactivity
Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor with an IC50 of 0.9 nM and minimal inhibition against Bcl-xl (IC50 > 1000 nM) . It is used in cancer research related to Bcl-2 family protein overexpression, particularly in hematologic malignancies like acute lymphoid leukemia, while minimizing the risk of side effects such as thrombocytopenia [1] by sparing Bcl-xl.
Smiles
O=[N+](C(C=C1S(NC(C(C=CC(N2C[C@H](N(CC2)CC3=C(C4=CC=C(C=C4)Cl)CC(C)(CC3)C)C)=C5)=C5OC6=CN=C(NC=C7)C7=C6)=O)(=O)=O)=C(C(F)=C1)NC[C@H]8COCCO8)[O-]
Molecular Formula
C45H49ClFN7O8S
Molecular Weight
902.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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