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FEN1-IN-7

Product Specifications

CAS Number

824983-90-6

Target

FLAP

Related Pathways

Immunology/Inflammation

Bioactivity

FEN1-IN-7 (compound 16), a selective Flap endonuclease-1 (FEN1) inhibitor with an IC50 of 18 nM, plays a role in DNA damage repair in mammalian cells. Additionally, it targets the related endonuclease, xeroderma pigmentosum G (XPG), with an IC50 of 3.04 ?M. FEN1-IN-7 enhances the sensitivity of cancer cells to potent DNA alkylating or methylating agents [1].

Smiles

C(N1C2=C(C(=O)N(O)C1=O)C(C)=CS2)C=3C=C4C(=C(OC)C3)OCO4

Molecular Formula

C16H14N2O6S

Molecular Weight

362.36

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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