CDK4/6-IN-17
Product Specifications
CAS Number
2035069-96-4
Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, exhibiting potent activity with IC50 values between 10-100 nM in BE (2) cells, and has demonstrated efficacy in inhibiting tumor growth in the COLO205 xenograft model [1].
Smiles
C(F)(F)[C@H]1N2C=3C(N=C2CC1)=C(F)C=C(C3)C4=NC(NC5=CC=C(CN6CCN(CC)CC6)C=N5)=NC=C4F
Molecular Formula
C27H28F4N8
Molecular Weight
540.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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