BVFP
Product Specifications
CAS Number
357158-20-4
Target
Neurotensin Receptor
Related Pathways
GPCR/G Protein
Purity
0.9874
Bioactivity
BVFP is a PGRN-SORT1 inhibitor/SORT1 antagonist that binds to key residues 588-593 of PGRN, a multifunctional secreted glycoprotein, and SORT1, a neuronal receptor for PGRN.BVFP is able to block PGRN-SORT1 binding, restore extracellular levels of PGRN , inhibits SORT1-mediated rPGRN endocytosis, and has therapeutic potential for frontotemporal lobe dementia (FTLD-TDP) .
Smiles
O=C1N=C(C=CC=2C=CC=C(Br)C2)C=C(N1)C(F)(F)F
Molecular Formula
C13H8BrF3N2O
Molecular Weight
345.12
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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