TH-Z827
Product Specifications
CAS Number
2847881-81-4
Target
Ras
Related Pathways
MAPK, GPCR/G Protein
Bioactivity
TH-Z827 is a mutant-selective inhibitor targeting KRAS (G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS (WT) or KRAS (G12C) . Additionally, it disrupts the KRAS (G12D) -CRAF interaction with an IC50 of 42 μM [1].
Smiles
O(C[C@H]1N(C)CCC1)C2=NC(=C3C(CN(CC3)C=4C5=C(C=CC4)C=CC=C5C)=N2)N6C7CCC6CNC7
Molecular Formula
C30H38N6O
Molecular Weight
498.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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