WWL0245
Product Specifications
CAS Number
2869057-11-2
Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Bioactivity
WWL0245 is a potent and selective BRD4-targeting PROTAC that exhibits sub-nanomolar degradation efficiency (DC50 < 1 nM) for BRD4 over BRD2/3 and PLK1 (DC50 > 1 μM) . It demonstrates pronounced selective cytotoxicity in BETi-sensitive cancer cell lines, particularly in AR-positive prostate cancer lines, making it a promising candidate for research in AR-positive prostate cancer and a valuable tool for the investigation of BRD4's biological function [1].
Smiles
C(N1C=2C(N3C([C@H]1CC)=NN=C3C)=CN=C(NC4=C(OC)C=C(C(NC5CCN(C(COC6=C7C(C(=O)N(C7=O)C8C(=O)NC(=O)CC8)=CC=C6)=O)CC5)=O)C=C4)N2)C9CCCCC9
Molecular Formula
C45H51N11O8
Molecular Weight
873.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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