JBI-589
Product Specifications
CAS Number
2308504-22-3
Target
Others, PAD
Related Pathways
Chromatin/Epigenetic, Others
Bioactivity
JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis. Additionally, it attenuates primary tumor growth and metastases, augmenting the efficacy of checkpoint inhibitors [1].
Smiles
C(N1C(=CC=2C1=CC=CC2)C3=C(C)N4C(=N3)C=C(C(=O)N5C[C@H](N)CCC5)C=C4)C6=CC=C(F)C=C6
Molecular Formula
C29H28FN5O
Molecular Weight
481.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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