PRMT5-IN-28
Product Specifications
CAS Number
2242753-66-6
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is involved in gene transcription, mRNA splicing, DNA repair, protein localization, cell fate determination, and signal transduction. Dysregulated PRMT5 activity contributes to oncogenesis by promoting cancer cell proliferation, apoptosis resistance, invasion, metastasis, and impacting immune evasion [1].
Smiles
O[C@H]1[C@H](N2C3=C(C=C2)C(=NOC)N=CN3)O[C@]([C@H](O)C4=CC=C(Cl)C=C4)([C@H]1O)[H]
Molecular Formula
C18H19ClN4O5
Molecular Weight
406.82
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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