TRK-IN-23
Product Specifications
CAS Number
2924344-29-4
Target
Apoptosis, Trk receptor
Related Pathways
Apoptosis, Tyrosine Kinase/Adaptors
Bioactivity
TRK-IN-23 (compound 24b) is a potent, orally active TRK inhibitor with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L, and 4.8 nM for TRKA G667C. It induces apoptosis in Ba/F3-TRKAG595R and Ba/F3-TRKAG667C cells [1].
Smiles
C(=C\1/C=2C(NC1=O)=CC=C(NCC3=C(OC)C=CC(F)=C3)C2)\C4=CN=CN4
Molecular Formula
C20H17FN4O2
Molecular Weight
364.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
