HNTS1R agonist-1

Compound 10, an hNTS1R agonist-1, acts as a full agonist with a strong affinity for hNTS1R (K i: 6.9 nM), showing the ability to cross the blood-brain barrier (BBB) . It not only enhances motor function but also improves memory in a mouse model of Parkinson's disease (PD) . Additionally, this compound is an analog of Neurotensin (8-13) and demonstrates neuroprotective properties [1].