HDHODH-IN-12
Product Specifications
Target
Dehydrogenase, DNA/RNA Synthesis
Related Pathways
Metabolism, DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
HDHODH-IN-12 is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting an inhibitory concentration (IC50) of 0.421 μM. As the rate-limiting enzyme in the de novo synthesis of pyrimidines, critical for DNA/RNA synthesis, DHODH is localized within the inner membrane of human mitochondria. hDHODH-IN-12 is applicable in lung cancer research [1].
Molecular Formula
C22H15F3N4O3
Molecular Weight
440.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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