SHP2-IN-22
Product Specifications
CAS Number
2802453-88-7
Target
Ras, Others, Phosphatase, Kras
Related Pathways
Others, MAPK, Metabolism
Bioactivity
SHP2-IN-22, a potent SHP2 allosteric inhibitor, exhibits an IC50 value of 17.7 nM and effectively suppresses proliferation, migration, and invasion in MIA PaCa-2 pancreatic cancer cells. This compound is utilized in the study of Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research [1].
Smiles
NC=1C(=NC=C(N1)N2CCN(C(NC3=CC(OC)=C(C#N)C=C3)=N)CC2)C4=C(Cl)C(Cl)=CC=C4
Molecular Formula
C23H22Cl2N8O
Molecular Weight
497.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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