SHP2-IN-22
Product Specifications
CAS Number
2802453-88-7
Target
Ras|||Others|||Phosphatase|||Kras
Related Pathways
Others|||MAPK|||Metabolism
Bioactivity
SHP2-IN-22, a potent SHP2 allosteric inhibitor, exhibits an IC50 value of 17.7 nM and effectively suppresses proliferation, migration, and invasion in MIA PaCa-2 pancreatic cancer cells. This compound is utilized in the study of Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research [1].
Smiles
NC=1C(=NC=C(N1)N2CCN(C(NC3=CC(OC)=C(C#N)C=C3)=N)CC2)C4=C(Cl)C(Cl)=CC=C4
Molecular Formula
C23H22Cl2N8O
Molecular Weight
497.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6489905-01 0.2 mL
NSE (Y236) (Gamma-enolase, 2-phospho-D-glycerate Hydro-lyase, Neural Enolase, Neuron-specific Enolase, NSE, Enolase 2, ENO2, NSE) (Azide free) (HRP)
Ask
View Details 
MBS6489905-02 5x 0.2 mL
NSE (Y236) (Gamma-enolase, 2-phospho-D-glycerate Hydro-lyase, Neural Enolase, Neuron-specific Enolase, NSE, Enolase 2, ENO2, NSE) (Azide free) (HRP)
Ask
View Details 244311-ML550 100 µL
CCL2 (Chemokine (C-C Motif) Ligand 2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF) (MaxLight 550)
Ask
View Details