GSK-3β inhibitor 15
Product Specifications
Target
Others, GSK-3, Apoptosis, Microtubule Associated
Related Pathways
PI3K/Akt/mTOR signaling, Others, Apoptosis, Stem Cells, Cytoskeletal Signaling
Bioactivity
GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-induced iNOS expression, demonstrating neuroprotective properties against Aβ 1-42-induced neurotoxicity and indicating potential utility in Alzheimer's disease (AD) research [1].
Molecular Formula
C17H16N6OS
Molecular Weight
352.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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