PLM-101
Product Specifications
Target
Others, FLT, c-RET
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Others, Apoptosis
Bioactivity
PLM-101 is an anticancer compound orally active against acute myeloid leukemia by targeting FLT3 and RET. It impedes RET function, promoting autophagic breakdown of FLT3, and suppresses the PI3K and Ras/ERK pathways, contributing to its anti-leukemic effects. The compound's antitumor efficacy is demonstrated in both a mouse MV4-11 flank xenograft model (doses of 3 and 10 mg/kg; po) and an allogeneic xenograft mouse model (dose of 40 mg/kg; po) [1].
Molecular Formula
C22H22FN5O2
Molecular Weight
407.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
E-CL-M0186-01 24 Tests
Mouse CCL3L1 -Chemokine C-C-Motif Ligand 3 Like Protein 1- CLIA Kit
Sign In for Pricing
View Details E-CL-M0186-02 48 Tests
Mouse CCL3L1 -Chemokine C-C-Motif Ligand 3 Like Protein 1- CLIA Kit
Sign In for Pricing
View Details E-CL-M0186-03 96 Tests
Mouse CCL3L1 -Chemokine C-C-Motif Ligand 3 Like Protein 1- CLIA Kit
Sign In for Pricing
View Details E-CL-M0186-04 5x 96 Tests
Mouse CCL3L1 -Chemokine C-C-Motif Ligand 3 Like Protein 1- CLIA Kit
Sign In for Pricing
View Details E-CL-M0186-05 10x 96 Tests
Mouse CCL3L1 -Chemokine C-C-Motif Ligand 3 Like Protein 1- CLIA Kit
Sign In for Pricing
View Details 