What is the catalog number for PLM-101?

The catalog number for PLM-101 is T78871.

What sizes are available for PLM-101?

PLM-101 is available in the following size(s): 5 mg, 50 mg.

How many pack sizes does PLM-101 come in?

PLM-101 is available in 2 different pack sizes.

PLM-101 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures PLM-101?

PLM-101 is manufactured by Molfinity.

What is the estimated delivery time for PLM-101?

Estimated delivery time for PLM-101 is approximately 10 business day(s), depending on your location.

PLM-101

Product Specifications

Target

Others, FLT, c-RET

Related Pathways

Angiogenesis, Tyrosine Kinase/Adaptors, Others, Apoptosis

Bioactivity

PLM-101 is an anticancer compound orally active against acute myeloid leukemia by targeting FLT3 and RET. It impedes RET function, promoting autophagic breakdown of FLT3, and suppresses the PI3K and Ras/ERK pathways, contributing to its anti-leukemic effects. The compound's antitumor efficacy is demonstrated in both a mouse MV4-11 flank xenograft model (doses of 3 and 10 mg/kg; po) and an allogeneic xenograft mouse model (dose of 40 mg/kg; po) [1].