TWIK-1/TREK-1-IN-1
Product Specifications
CAS Number
1440532-30-8
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and TWIK-1/TREK-1 heterodimers, both significant for its role as an antidepressant target. Furthermore, TWIK-1/TREK-1-IN-3, a related compound, selectively inhibits these channels with IC50 values of 9.36 μM for TREK-1 homodimers and 14.6 μM for TWIK-1/TREK-1 heterodimers, demonstrating antidepressant-like effects [1].
Smiles
OC1(CCN(C[C@H](COC2=CC=C(C(F)(F)F)C=C2)O)CC1)C3=CC=CC=C3
Molecular Formula
C21H24F3NO3
Molecular Weight
395.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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