Anticancer agent 157
Product Specifications
Target
Caspase, Apoptosis, NO Synthase
Related Pathways
Apoptosis, Immunology/Inflammation, Proteases/Proteasome
Bioactivity
Anticancer Agent 157 (compound 15) is a nitric oxide (NO) inhibitor with IC50 values of 0.62 μg/mL, exhibiting both anti-inflammatory and anticancer effects. It interacts with inducible NO synthase (iNOS) and caspase 8, which facilitates apoptosis through nuclear fragmentation and chromatin condensation. Additionally, Anticancer Agent 157 effectively inhibits HT29 colon cancer cells (IC50 =2.45 μg/mL), Hep-G2 liver cancer cells (IC50 =3.25 μg/mL), and B16-F10 murine melanoma cells (IC50 =3.84 μg/mL) [1].
Molecular Formula
C14H20O2
Molecular Weight
220.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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