WK499
Product Specifications
Target
Others, Apoptosis, Bcl-2 Family
Related Pathways
Apoptosis, Others
Bioactivity
BCL6-IN-10 (Compound WK499) is an inhibitor of BCL6 that disrupts its interaction with the SMRT protein, promoting apoptosis, cell cycle arrest, and DNA damage. It effectively hampers the proliferation of various AML cell lines, with IC50 values of 0.91, 1.63, 1.026, 7.42, 0.87, and 0.85 μM for OCI-AML3, THP1, MOLM13, HL60, KG1, and NB4 cells, respectively [1].
Molecular Formula
C21H20BrN7O3
Molecular Weight
498.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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