ERD-3111
Product Specifications
CAS Number
2832865-25-3
Target
PROTACs, Estrogen Receptor/ERR
Related Pathways
PROTAC, Endocrinology/Hormones
Bioactivity
ERD-3111 (Compound 44), an orally active PROTAC ERα degrader (DC50: 0.5 nM), exhibits efficacy in inhibiting tumor growth in both the parental MCF-7 xenograft model harboring wild-type ER and two ESR1-mutated mouse models. This compound has utility in the investigation of ER+ breast cancer [1].
Smiles
C(C(F)F)N1[C@@H](C2=C(C3=C(C=C2)NN=C3)C[C@H]1C)C4=C(F)C=C(C=C4F)N5CCC6(CC5)CCN(C(CN7CC=8C(C7)=CC9=C(C8)C(=O)N(C9=O)C%10C(=O)NC(=O)CC%10)=O)CC6
Molecular Formula
C45H46F4N8O5
Molecular Weight
854.89
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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