PROTAC AR-NTD degrader 1
Product Specifications
Target
Apoptosis, Androgen Receptor
Related Pathways
Apoptosis, Endocrinology/Hormones
Bioactivity
PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule from the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal domain (AR-NTD) of the Androgen Receptor variant AR-V7. By antagonizing AR-NTD, it effectively degrades AR-V7 protein and induces apoptosis in prostate cancer (PC) cells, with degradation efficiencies of 62.2% (1 μM) and 71.1% (5 μM) in VCaP cells [1].
Molecular Formula
C41H47ClN6O7
Molecular Weight
771.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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