SIRT5 inhibitor 7
Product Specifications
CAS Number
2951090-00-7
Target
Sirtuin
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair
Purity
0.9977
Bioactivity
SIRT5 inhibitor 7 (compound 58), a substrate-competitive and selective SIRT5 inhibitor with IC 50 = 310 nM, significantly attenuated renal dysfunction and pathological damage in lipopolysaccharide (LPS) - and cecum ligation/perforation (CLP) -induced septic AKI mice, and modulated proteinsuccinimidylation and proinflammatory cytokine release and pro-inflammatory cytokine release in the kidneys of acute kidney injury (AKI) mice.
Smiles
N(CCCNC(NCCC(O)=O)=S)C=1C(C(=O)N2C[C@H](CC2)C3=CC=CC=C3)=CN=C(NC4=C(Cl)C=CC=C4)N1
Molecular Formula
C28H32ClN7O3S
Molecular Weight
582.12
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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