J-1048

Product Specifications

CAS Number

2374772-60-6

Target

ALK|||Others

Related Pathways

Tyrosine Kinase/Adaptors|||Angiogenesis|||Others

Bioactivity

J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-?/Smad signaling pathway [1].

Smiles

C(C(NC1=CC(F)=CC=C1)=S)N2C=C(C(=N2)C=3N=C(C)C=CC3)C4=CC=5C(C=C4)=NSN5

Molecular Formula

C23H17FN6S2

Molecular Weight

460.55

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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