PROTAC BTK Degrader-6

Product Specifications

CAS Number

2767204-39-5

Target

PROTACs|||BTK

Related Pathways

Angiogenesis|||PROTAC|||Tyrosine Kinase/Adaptors

Bioactivity

PROTAC BTK Degrader-6 (Compound 15), with a DC50 of 3.18 nM, exhibits anti-inflammatory properties by inhibiting NF-?B activation and suppressing the expression of pro-inflammatory cytokines such as IL-1? and IL-6 [1].

Smiles

NC1=C2C(=NN(C2=NC=N1)C3CCN(C(CN4CCN(CC5CN(C5)C=6C=C7C(=CC6)C(=O)N(C7=O)C8C(=O)NC(=O)CC8)CC4)=O)CC3)C9=CC=C(OC%10=CC=CC=C%10)C=C9

Molecular Formula

C45H47N11O6

Molecular Weight

837.92

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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