SIKs-IN-1
Product Specifications
CAS Number
2927557-06-8
Target
Others, SIK
Related Pathways
PI3K/Akt/mTOR signaling, Others
Bioactivity
SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in M1/M2 macrophage polarization linked to inflammation. By inhibiting SIK activity, this compound increases anti-inflammatory cytokine IL-10 and decreases pro-inflammatory cytokine IL-12, demonstrating significant anti-inflammatory efficacy in a DSS-induced colitis model [1].
Smiles
C(NC1=C(C)C=CC=C1F)(=O)C=2C(NC3CCC3)=NC(NC4=CC(F)=C(C=C4)N5CCN(C)CC5)=NC2
Molecular Formula
C27H31F2N7O
Molecular Weight
507.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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