TNF-α-IN-11
Product Specifications
Target
TNF, Others, Caspase, NF-κB
Related Pathways
Apoptosis, Proteases/Proteasome, NF-κB, Others
Bioactivity
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor with a dissociation constant (K D) of 12.06 μM. It impedes TNF-α-induced caspase activation and the NF-κB signaling pathway by binding to TNF-α, suppressing the phosphorylation of IκBα and the nuclear migration of NF-κB p65. This compound is utilized in the study of TNF-α-mediated autoimmune diseases [1].
Molecular Formula
C24H26N2O5
Molecular Weight
422.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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