MS78
Product Specifications
Target
Others, MDM-2/p53, Histone Acetyltransferase
Related Pathways
Apoptosis, Others, Chromatin/Epigenetic
Bioactivity
MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP. This compound enhances the expression of TRAIL apoptotic genes while concurrently suppressing DNA damage response pathways. Its structure comprises a CBP/p300 binding domain, a p53Y220C targeting moiety, and a connecting linker [1].
Molecular Formula
C57H66FN9O6S
Molecular Weight
1024.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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