A011
Product Specifications
Target
ATM/ATR, Apoptosis
Related Pathways
Apoptosis, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling
Bioactivity
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumor activity [1].
Molecular Formula
C27H28N6O
Molecular Weight
452.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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