JAK/HDAC-IN-2
Product Specifications
Target
Apoptosis, JAK, HDAC
Related Pathways
JAK/STAT signaling, DNA Damage/DNA Repair, Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis, Chromatin/Epigenetic, Stem Cells
Bioactivity
JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations. This compound exhibits proapoptotic properties, inhibits histone deacetylation, and impedes STAT3 phosphorylation, demonstrating notable antiproliferative activity against various hematological malignancies and solid tumors [1].
Molecular Formula
C28H38N6O5S
Molecular Weight
570.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC680097-100 1x 100 µL
Nuclear Membrane (NM97), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details ![CATIP Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1A6]](https://cdn.genprice.uk/products/937/68dd1b70061270361ea18140/imageurl/ta505507am.webp)
TA505507AM 100 µL
CATIP Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1A6]
Sign In for Pricing
View Details 
BCBT-106 Each
Weak acid and alkali Chemical storage cabinet BCBT-106
Sign In for Pricing
View Details 
TRC-B693040-50MG 50 mg
N-tert-Butyl-3-(2-hydroxypropan-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide
Sign In for Pricing
View Details 
BNC942276-500 1x 500 µL
CD52 (Epididymis-Specific Protein 5) (CD52/2276R), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details