JAK/HDAC-IN-2
Product Specifications
Target
Apoptosis, JAK, HDAC
Related Pathways
JAK/STAT signaling, DNA Damage/DNA Repair, Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis, Chromatin/Epigenetic, Stem Cells
Bioactivity
JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations. This compound exhibits proapoptotic properties, inhibits histone deacetylation, and impedes STAT3 phosphorylation, demonstrating notable antiproliferative activity against various hematological malignancies and solid tumors [1].
Molecular Formula
C28H38N6O5S
Molecular Weight
570.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TRC-A158450-250MG 250 mg
4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid, Sodium Salt
Sign In for Pricing
View Details 
TP720520 10 µg
Cysteine Dioxygenase Type 1 (CDO1) (NM_001801) Human Recombinant Protein
Sign In for Pricing
View Details 