I-287
Product Specifications
CAS Number
2014368-93-3
Target
Others, ERK, Protease-activated Receptor
Related Pathways
MAPK, Others, GPCR/G Protein
Bioactivity
I-287 is a selective, orally active PAR2 inhibitor that functions as a negative allosteric modulator of Gαq and Gα12/13 activity and their downstream effectors. It has been shown to attenuate Complete Freund's adjuvant-induced inflammation in mice, suggesting its utility in inflammation/immunology research [1].
Smiles
C(C)(C)(C)C1=C2C(=NC(=C1)C3=CC(F)=C(Cl)C=C3)C=C(C(=O)N4C(C)(C)CN(CC4)C5=CC=C(C(O)=O)C=N5)O2
Molecular Formula
C30H30ClFN4O4
Molecular Weight
565.04
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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