2′-Thioadenosine
Product Specifications
CAS Number
136904-69-3
Target
EGFR
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis
Bioactivity
2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 μM against ErbB-2. It achieves covalent inactivation of ErbB-1 through modification of a cysteine residue within the enzyme's active site [1].
Smiles
S[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CO)[C@H]1O
Molecular Formula
C10H13N5O3S
Molecular Weight
283.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb1055289 100 µL
HIF Prolyl Hydroxylases Rabbit Polyclonal Antibody (Cy7)
Sign In for Pricing
View Details MBS1124479-01 0.02 mg (E-Coli)
Recombinant Bacillus cereus Adenine phosphoribosyltransferase (apt)
Sign In for Pricing
View Details MBS1124479-02 0.1 mg (E-Coli)
Recombinant Bacillus cereus Adenine phosphoribosyltransferase (apt)
Sign In for Pricing
View Details