2′-Thioadenosine
Product Specifications
CAS Number
136904-69-3
Target
EGFR
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis
Bioactivity
2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 μM against ErbB-2. It achieves covalent inactivation of ErbB-1 through modification of a cysteine residue within the enzyme's active site [1].
Smiles
S[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CO)[C@H]1O
Molecular Formula
C10H13N5O3S
Molecular Weight
283.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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