PB118
Product Specifications
Target
Others, HDAC
Related Pathways
Others, Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
PB118 has the capacity to effectively clear Aβ deposits by augmenting phagocytosis, enhance the tubulin/microtubule network through increased acetyl α-tubulin levels, modulate various inflammation-associated cytokines and chemokines, and notably diminish phospho-tau (p-tau) levels linked to Alzheimer's disease (AD) . The IC50 of PB118 for HDAC6 is 5.6 nM.
Smiles
O=C(NO)C1=CC(F)=C(CN2CCCCC3=CC=CC=C32)C=C1
Molecular Formula
C18H19FN2O2
Molecular Weight
314.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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