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NSC194598

Product Specifications

CAS Number

5358-76-9

Target

C-RET, Others

Related Pathways

Tyrosine Kinase/Adaptors, Apoptosis, Others

Bioactivity

NSC194598, a p53 DNA-binding inhibitor, demonstrates an in vitro IC50 of 180 nM and an in vivo range of 2-40 μM. It disrupts the transcriptional activation of the mutated RET gene in human medullary thyroid carcinoma TT cells and is utilized in research investigating acute toxicity in normal tissues due to radiation and chemotherapy [1] [2].

Smiles

O=N=1C(=NC2=CC=CC=3C=4C=CC=CC4C1C23)CN5CCCCC5

Molecular Formula

C20H19N3O

Molecular Weight

317.38

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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